I presume some of these suggestions are being made in jest.

Although regulars will fairly confidently board their bus if heading in the right direction despite the driving having failed to change the destination from the previous journey, it would be stupid to suggest we do away with destinations completely, or route numbers in favour of route names as others have done.

The bus network must be simple to understand and easy to use at the end of the day, not just for the regulars but for the infrequent and new users too. 

People unfamiliar with the area/direction of travel should be able to quickly board an approaching bus with a suitable destination displayed without having to study the literature displayed at the stop first. 

Likewise a reason for keeping route numbers, colour blind or partially sighted people may not rely on route branding, and people with little/no English or who cannot read at all would find it more difficult to identify a route name over a route number.